Looking to do something that'll make a difference in people's lives, a meaningful way to celebrate the Thanksgiving season? Why not consider Kiva:
Kiva is a world-wide microfinance organization. People from all around the world lend money to small businesspersons and others in the third world to help them obtain the capital they need to manage their businesses successfully. The borrowers then pay the loan back over time and the lender can relend the money or withdraw it.
It's a great way to help the poor help themselves and a wonderful way to express your gratitude for all that you have.