One of the strongest arguments against any naturalistic theory of the origin of life is the enormous difficulty inherent in the attempt to give a plausible account of how the first cells could have ever been formed.
One of the problems for origin of life researchers is that even the simplest cell is immensely complex, consisting of thousands of molecular machines that must all be present and functioning in a coordinated manner in order for any cell to survive. And of course until there are living cells there could be no evolution of the sort described in high school and college biology textbooks.
This short video gives just a glimpse of the intractable nature of the problem. Don't be put off by the cartoonish graphics. The content is very sophisticated but also easily understood by anyone with a high school science education.
Check it out: