Clarice Feldman of The American Thinker has a pair of posts here and here on the Damadola airstrike that sheds some light on exactly how well-planned the attack was and who was killed in it. Feldman thinks Zawahiri was among the casualties but that no one wants to say so definitively since his corpse has not been recovered.
Not counting Zawahiri, it looks like six senior al-Qaeda leaders were in the houses that were struck. Feldman quotes milblogger Dan Darling:
I have a Weekly Standard piece on the death of Abu Khabab coming out pretty soon, but for those who are interested here are all of the al-Qaeda leaders who have been listed as being killed in Damadola at present according to media reports:
Abu Khabab al-Masri (WMD committee head); Abd Rahman al-Masri al-Maghribi (al-Zawahiri's son-in-law, al-Qaeda commander); Abu Ubeidah al-Masri (Kunar operations chief); Marwan al-Suri (Waziristan operations chief); Khalid Habib (southeastern Afghanistan commander); Abdul Hadi al-Iraqi (southwestern Afghanistan commander);
Add to that Maulana Faqir Mohammed and Maulana Liaqat (local leaders of the Tehrik Nifaz-e-Sha'riah Mohammed, apparently) and it looks like that was quite a dinner they had planned. I would have settled for nailing Khabab alone, but this looks like the biggest single decapitation strike on the al-Qaeda leadership since Tora Bora.
If the terrorists are now realizing that they can't hide forever even in a desolate place like Waziristan, if they're realizing that they're nowhere safe, it will have the effect of considerably ratcheting up the stress and weariness that must already afflict them. This in turn, one hopes, will lead to careless decisions, producing more casualties, which will lead to yet more stress, and so on in a runaway feedback loop.
The problem for the senior leadership is there's no way out. They can't surrender nor can they just quit their war and go home. To do either would be the psychological nail in the coffin of global jihad. The only path left to them is to fight and sooner or later be suddenly killed by an unseen predator drone and a hellfire missile. That realization must be extremely hard on those men and their families, but they asked for this hell in which they live and which they've created for others. They have made it clear that they are at war with the West, a fight to the death.
There's no easy way out for us either. We must either fight or, eventually, capitulate to Islamic will. Either we relentlessly pursue the al-Qaeda leadership and thoroughly demoralize those who follow them or we can look forward to a world where our granddaughters wear burkhas and our grandsons memorize the Koran. Either we defeat them or watch darkness descend over the world. There's no other alternative.