Materialism is the philosophical view that matter is all there is and that everything can therefore ultimately be reduced to, and explained in terms of, material entities. Terry Mirl offers six predictions based on materialism which, assuming that view were true, should eventually be confirmed. If, after a suitable period of time, these predictions have not come to pass, the lack of confirmation should be taken as an indication, Mirl claims, that materialism is false.
His six predictions are quite provocative. If you read them, ask yourself what you think the likelihood is of any of them ever being fulfilled and what the implications of that might be. You can find them at Uncommon Descent.