Since bones are made by many individual (and independent) bone cells, building a bone is an inherently distributed problem. How do the individual bone cells know where to be, and where and how much calcium to deposit? How is this managed over the body's development cycle, as the sizes and shapes of many of the bones grow and change?Here's another question: How do bones know when to stop growing? Where is the information located that tells each bone to stop? How is that information turned on and off and how is it translated into chemical signals and how do those signals work?
Surely the specifications for the shapes, their manufacturing and assembly instructions, and their growth patterns must be encoded somewhere. There must also be a three-dimensional coordinate system for the instructions to make sense.
Is the information located in each bone cell, or centrally located and each individual bone cell receives instructions? If each bone cell contains the instructions for the whole, how does it know where it is in the overall scheme? How do all those bone cells coordinate their actions to work together rather than at odds with each other?
As yet no one has answers to these questions. One thing we can expect, though: whoever solves these mysteries will likely win a Nobel Prize - which invites a question: If it takes someone of a Nobel-caliber brilliance to answer such questions, why wouldn't it have taken similar or greater intelligence to engineer it in the first place?
Furthermore, why is it that the ossicles in the middle ear, the "hammer," "anvil" and "stirrup," are full-size at birth and are the only bones in the body that don't grow as the body grows? How is that unique specification coded and transmitted only to these bones and no others?
And how is all of that produced by an unguided, mindless process like naturalistic evolution?