Michael Egnor employs the strange case of Phineas Gage to argue that materialism is self-refuting. He observes, for example, that:
Brain matter cannot be the complete cause for ideas because matter and ideas share no properties. Cause and effect can't be 'linked' between substances that have no properties in common.
I believe that materialism is incapable of providing an adequate explanation for the mind. Clearly ideas can influence the movement of matter (via the brain), and vice-versa, but materialism alone is inadequate to explain the link. The link between the mind and the brain must involve agency that has such non-material properties as purpose and judgment, and, as such, an adequate explanation for the mind must necessarily be open to immaterial causes.
Egnor makes an interesting argument for what philosophers call substance dualism, the belief that reality is comprised of two disparate essences, mind and matter. Materialists, of course, believe that matter is all there is. His essay can be read at the link.RLC