Looking to do something that'll make a difference in people's lives? Why not consider Kiva: Kiva is a world-wide microfinance organization. The way it works is people from all around the globe lend money to small businesspersons and others in the third world to help them obtain the capital they need to manage their businesses successfully. The borrowers then pay the loan back over time, and the lender can relend the money or withdraw it.
It's a great way to help the poor help themselves and a wonderful opportunity to express your gratitude for all that you have by "paying it forward". You can learn more about how Kiva works at the link.