In the interview Margulis says the following:
All scientists agree that evolution has occurred...The question is, is natural selection enough to explain evolution?...This is the problem I have with neo-Darwinists: They teach that what is generating novelty is the accumulation of random mutations in DNA, in a direction set by natural selection....Natural selection eliminates and maybe maintains, but it doesn’t create....I was taught over and over again that the accumulation of random mutations led to evolutionary change — led to new species. I believed it until I looked for evidence....There is no gradualism in the fossil record....‘Punctuated equilibrium’ was invented to describe the discontinuity....The critics, including the creationist critics, are right about their criticism. It’s just that they’ve got nothing to offer but intelligent design or ‘God did it.’ They have no alternatives that are scientific....The evolutionary biologists believe the evolutionary pattern is a tree. It’s not. The evolutionary pattern is a web....Prof. Margulis is correct that ID advocates can't explain how an intelligent agent might have engineered life, but I don't see why that should be an impediment to believing that one did. There are lots of things, after all, that scientists believe even if they can't explain how those phenomena came to be. For example, no one can explain how an electron can be in two places at the same time when it's not being observed, or how the universe came into being out of nothing, or how the material brain produces the sensations of color and flavor, etc., or how matter generates gravity, or how magnets repel, or how radioactive decay occurs, and on and on. Nevertheless, despite our inability to explain how these phenomena happen, scientists all believe they do.
The same is true with the origin and diversity of life. It may be that we'll never know exactly how life was originally created, but that's no reason to doubt that it somehow required intelligent input.
Put another way, if the first astronauts to land on the moon had found an American flag already there, they may have had no idea how it could have happened, but that doesn't mean they would doubt that it was placed there by an intelligent agent. They wouldn't think that it was the product of a chance accident of some sort.
It'd be foolish to resist believing that an intelligent agent was responsible for the flag being there just because we cannot explain how the agent did it. Likewise, so much of life points beyond chance to intelligent agency that it's foolish to rule this possibility out simply because no one knows how the agent would, or could, have acted.
I'm reminded of the wise words of William James who wrote that "a rule of thinking which would absolutely prevent me from acknowledging certain kinds of truth, if these kinds of truth were really there, would be an irrational rule."
So it would.