One of the most serious scientific threats to the belief of many moderns that the natural world is all there is (i.e. Naturalism) is the problem posed by trying to explain how life could have arisen on this planet through purely natural, unguided, random processes. The problem is daunting as the video below illustrates.
Once living cells appeared on the earth, the naturalist can argue, reproduction and natural selection can be invoked to account for the diversification of life into all the forms of living things we see in our world today, but how did those initial cells arise in the first place? Genetic mutation and natural selection, the traditional mechanisms of evolution, can only operate on reproducing populations of organisms, but until you have reproducing cells with something like genes that can mutate you can't have evolution.
Trying to explain how those original cells arose is like trying to explain how the laws of chemistry and physics could have organized a pile of atoms into a functioning computer complete with an operating system without any input from an intelligent engineer.
A living cell consists of hundreds of different proteins all serving different functions in the cell. The video explains the difficulties involved in the chance production of just a single functional protein.
Even if somehow those odds were overcome an unimaginable number of times and all the requisite proteins were somehow available to form a cell, how did they manage to randomly integrate themselves into an organized, functioning entity? Where did the information come from that directed these proteins to work together to perform specific tasks? How did the information arise that choreographed the proteins' ability to reproduce themselves and that choreographed the cell's ability to reproduce itself?
Despite assurances in the 20th century that scientists were on the cusp of elucidating how all this came about on the primeval earth, the problem has proven intractable. The origin of life is perhaps one of the three most perplexing problems in biological science today, along with the puzzle of how consciousness could have evolved out of inanimate matter and the problem of explaining the provenience of the biological information which programs cellular structures to perform the myriad functions and activities they carry out twenty four hours a day.
Conscious beings only seem to arise from other conscious beings. Information, such as is found in books or in computer operating systems, is only generated by minds. It may be that someday scientists will produce life from non-living matter in the laboratory, but if so, they will have only demonstrated that life, too, can be produced by the effort of conscious minds.
The problem of how the first life can be accounted for in a naturalistic ontology will still remain, and it will still require an heroic exertion of blind faith to believe that against incomprehensible odds, somehow, in ways we can't even as yet imagine, life appeared.
It requires more faith to believe this, actually, than it does to believe in miracles. With miracles, after all, there's an intelligent, conscious Agent responsible for the miracle. On Naturalism there's nothing but blind, unguided accident.